Search on: JNK SIGNALING PATHWAY 
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Descriptor English:   MAP Kinase Signaling System 
Descriptor Spanish:   Sistema de Señalización de MAP Quinasas 
Descriptor Portuguese:   Sistema de Sinalização das MAP Quinases 
Synonyms English:   ERK Pathway
ERK Signal Tranduction Pathway
ERK1 and ERK2 Pathway
ERK1-2 Pathway
JNK Pathway
JNK Signaling Pathway
MAP Kinase Modules
MAP Kinase Signaling Cascades
MEK-ERK Pathway
p38 Kinase Pathway
p38 Kinase Signaling Pathway
Cascade, MAP Kinase
ERK Pathways
ERK1 2 Pathway
ERK1-2 Pathways
JNK Pathways
JNK Signaling Pathways
Kinase Cascade, MAP
Kinase Pathway, p38
Kinase Pathways, p38
MAP Kinase Cascades
MAP Kinase Module
MEK ERK Pathway
MEK-ERK Pathways
Module, MAP Kinase
Pathway, ERK
Pathway, ERK1-2
Pathway, JNK
Pathway, JNK Signaling
Pathway, MEK-ERK
Pathway, p38 Kinase
Pathways, ERK
Pathways, ERK1-2
Pathways, JNK
Pathways, JNK Signaling
Pathways, MEK-ERK
Pathways, p38 Kinase
Signaling Pathway, JNK
Signaling Pathways, JNK
p38 Kinase Pathways
MAP Kinase Cascade
MAP Kinase Signaling Pathways  
Tree Number:   G02.111.820.560
G03.493.560
G04.835.560
Definition English:   An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. 
See Related English:   MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
 
History Note English:   2000 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   34468 
Unique Identifier:   D020935 

Occurrence in VHL: 		 

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